The Department of Transportation (DOT) is responsible for all aspects hazardous materials transportation. Unlike many other agencies, DOT regulations cannot be superseded by more stringent state regulations.

The Department of Homeland Security (DHS) is responsible for securing the United States against terrorist attack.

The Department of Commerce, Export Administration regulates international commerce of explosive materials. These regulations are found in 15 CFR.

The Environmental Protection Agency (EPA) is responsible for regulating the transportation of hazardous waste.  Shipments of all hazardous waste materials must be accompanied by a Uniform Hazardous Waste Manifest.  Regulations governing the use of the manifest are found at 40 CFR Parts 260, 261, 262, 263, 264, 265 and 271.