The Department of Labor (DOL), Occupational Safety and Health Administration (OSHA) is responsible for ensuring the safety of workers in the manufacture of explosive materials. These regulations are found in 29 Code of Federal Regulations (CFR), Part 1910.109.

The Department of Justice (DOJ)Bureau of Tobacco, Alcohol, Firearms and Explosives is responsible for licensing explosives manufactures, security clearances of employees and establishing standards for the storage of explosives incidental to the manufacture of explosives.  These regulations are found in 27 CFR, Part 555.

The Department of Homeland Security (DHS) is responsible for securing the nation's critical infrastructure from terrorist attack.  Chemical facilities, including those that manufacture explosives, are a discrete sector of the nation's critical infrastructure.

The Environmental Protection Agency (EPA) is responsible for regulating all manufacturing activities that involve or may involve a release of regulated pollutants or chemical substances to the environment.  EPA regulations also govern past/historical releases associated with manufacturing activities, and regulate the management of any hazardous wastes generated by the manufacturing process.   EPA regulations are published at Title 40 Chapter I (Parts 1-799), Chapter V (Parts 1500 - 1517), and Chapter VI (Part 1700).